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Chemical BiologyGillingham Research Group

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A figure summarizing the paper.
/ News, Research, Doctorate/PhD, Publication

A covalent click-to-release strategy to selectively kill cancer cells

Matthias Schild combines in his RCS Med. Chem. article a covalent EGFR-targeting small molecule, inverse electron-demand Diels-Alder chemistry, and a very strong cytotoxin to seletively only specific cells.

A "TOC" image summarizing the main point of the paper: That the genome of HEK293 cells was changed so that pomalidomide can degrade PALB2 via the 26S proteasome.
/ News, Research, Doctorate/PhD, Publication

Is PALB2 a good drug target?

Is PALB2 a good drug target? This is the question that Xinyan Lu tried to answer during his PhD with us by applying many tools from chemical biology to study homologous recombination.

A small picture visualizing the gist of the paper.
/ News, Research, Doctorate/PhD, Publication

Expanding the DEL toolset: A functional approach to DEL selections

While normal DELs find hits based on their ability to bind a molecule, this new approach sets the foundation to search specifically for molecules that cause ubiquitin transfer from CRBN-E3-Ligase to a POI.

Pedro at the beginning of his defense
/ Studies, Doctorate/PhD, Events, Graduated!

Congratulations, Dr. Mota

After a bit more than four years, Pedro Mota successfully defended his thesis titled "Exploring covalent ligands for the E3 ligase substrate receptor DCAF15 as an approach for the recruitment of neosubstrates"

An "table of content" picture showing that a Pan-Kinase inhibitor against p110α, p110β, p110γ, p110δ and mTOR can selectively degrade only one of these, namely p110α.
/ News, Research, Doctorate/PhD, Publication

Turning a pan-inhibitor into a selective degrader

In our newest publication from Werner Jauslin, you can dive into a story where we turned a pan-selective PI3K inhibitor into a selective PI3Kα degrader by having a specific linker.

Werner giving his Defense
/ News, Studies, Doctorate/PhD, Events, Graduated!

Congratulations, Dr. Jauslin

After four years, Werner Jauslin successfully defended his PhD thesis titled "Exploring PI3Ks and related kinases in targeted protein degradation"

A portrait image of Dr. Lukas Schneider
/ News, Research, People, Info

Dr. Lukas Schneider receives the DMCCB PhD Thesis Prize 2024

Dr. Lukas Schneider receives the DMCCB PhD Thesis Prize 2024 for his excellent PhD thesis "A novel selection approach for DNA-encoded libraries using terminal deoxynucleotidyl transferase".

A picture of our new group members with a carussel in the back. From left to right: Giulia, Chiara, Minqi and Athira.
/ News, Doctorate/PhD, Events, People, New group member

A trip to Herbstmesse - and a welcome to our new groupmembers!

After our research report, we went to Herbstmesse and introduced our new group members to the traditional Chääsbängel lunch.

A image showing the concept of the method described in the paper.
/ News, Research, Publication

A new method to select hits in DNA encoded libraries

Our very first JACS paper is about DNA encoded libraries. It describes a novel method to select for hits that performs significantly better than affinity selections - the industry standard (so far). And the best of it - its compatible to…

Dr. Lukas Schneider in front of his poster.
/ News, Research, Doctorate/PhD

A new DEL STAR on the horizon

Dr. Lukas Schneider won the poster prize for his amazing DELSTAR system at the 11th international DNA-encoded library symposium narrowly over a fascinating native MS poster from a collaborator of Jörg Scheuermann. Congratulations!

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