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Nature's kill switch for protein degradation

A teaser image showing the degradation process of a protein-of-interest fusion with MGMT via the 26S proteasome. Depicted are also two pseudosubstrates benzylguanine and lomeguatrib.

Are you looking to get rid of overexpressed proteins in cells?

Imagine you overexpress a protein in cells. And, for whatever reason, want to get rid of it. Fast. Without waiting for the normal processes to take care of it.

Don't fret any further! In our biggest collaboration to date, we show how to use the damage repair protein MGMT as a damage tag to conveniently get rid of overexpressed proteins.