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A DNA‐encoded chemical library incorporating elements of natural macrocycles

Artistic display of a macrocycle binding to a protein target.

Artistic display of a macrocycle binding to a protein target (Universität Basel, Basilius Sauter, CC BY-SA 3.0)

Our publication in Angewandte Chemie shows a seven-step synthesis of a DNA encoded macrocycle library. The library was designed with a rich backbone diversity, including over 2000 different scaffolds inspired by natural products.

 

doi:10.1002/anie.201902513